A major revolution in disease treatment is breaking: Gene editing as a way to treat hereditary and other diseases by epigenetic modification rather than DNA change.

CRISPR-Cas9 technique targeting epigenetics reverses disease in mice

A modified CRISPR-Cas9 technique can treat disease, not by changing the genes themselves but by altering their activity. This avoids the possibility of introducing mutations. Thus far researchers have restored normal kidney function in mice with acute kidney disease, improved the health of type 1 diabetic mice by getting their pancreas to make insulin, and improved muscle function and growth in a mouse model of muscular dystrophy. They hope for future treatments for neural disorders.

Their complex of virus-assisted enzymes ...

… sits in the region of DNA of interest and promotes expression of a gene of interest. Similar techniques could be used to activate virtually any gene or genetic pathway without the risk of introducing potentially harmful mutations.

Their findings are the first to provide evidence that one can alter the phenotype of an animal with a epigenetic editing technology, preserving DNA integrity.

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Now THIS is proper medicine! The progress toward the first "True" Civilisation continues...

Thank you Ruth! I love hearing about fascinating science advancements!


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