I'm crossing my fingers on the thought that it may be like BG. I'm a little concerned though that it may be a little too open-ended (Fable, Oblivion, etc.) for my preference. Don't get me wrong, I liked those games a lot but I am a D&D girl at heart and sort of like the stronger central storylines, (as well as very well-developed NPCs) you know?
Resident Evil 5? I have personally beaten Resident Evil 4 on both GC and PS2 around... i lost track around 30 times, not to mention assignment ada and mercenaries...
Starcraft Deux! I have been playing the original for around six years, and during the summer I tend to spend 14 hours playing, 10 hours sleeping and only taking breaks to eat and excrete. Very hesitant, I tend to dislike 3D RTS's.
Diablo Trois! Basically anytime during a summer where I wasn't playing SC, i was playing D2.
BTW: I have personally run through two copies of Diablo II, 2 of the exppac, 4 copies of SC, 3 of BW, and my GC broke before my RE4 did -> after it broke I just got it for the PS2.