Randall mentioned taking NMN supplements to slow aging. I've been taking it for a few months. New information, from a couple of mouse studies, suggests it may help to prevent or slow Alzheimer's.
The first study indicates that amyloyd beta (Abeta) accumulation in spaces between neurons triggers an inflammatory reaction by the neurons involving inflammasomes. This makes Abeta accumulation worse, and also causes hyperphosphorylation of tau proteins, and tau pathology.
Tau proteins usually stabilize a neuron's skeleton. However, in Alzheimer's disease, frontotemporal dementia (FTD), and other "tauopathies" these proteins are chemically altered, they detach from the cytoskeleton and stick together.
… inflammatory processes triggered by the brain's immune system are a driving force.
A particular protein complex, the "NLRP3 inflammasome," plays a central role for these processes,…
…this macromolecule, which is located inside the brain's immune cells… is a molecular switch that can trigger the release of inflammatory substances.
… the researchers discovered that the inflammasome influences enzymes that induce a "hyperphosphorylation" of tau proteins.
"Our results support the amyloid cascade hypothesis for the development of Alzheimer's. According to this hypothesis, deposits of Abeta ultimately lead to the development of tau pathology and thus to cell death," said Heneka.
The second study found that in a mouse model of Alzheimer's NAD+ treatment (by injection into abdominal cavity) reduced amyloid plaques that had already formed and improved mental performance.
- NAD⁺ treatment reduces amyloid plaques present in the cortex and hippocampus.
- NAD⁺ alleviated the spatial learning and memory deficits associated with increased senile plaques.
NMN sublingual supplements are a similar NAD+ therapy, because stomach acid decomposition is avoided. NAD⁺ injection restores NAD⁺ levels in brain and cognition in mice ...
In sum, our best strategy to keep our brains intact as we age includes not only eating right and exercise but also daily sublingual NMN (Nicotinamide MonoNucleotide).
A personal anecdote. After I'd begun taking MNM, a fingernail which had been growing in split for at least a year returned to normal.
On a related note, a subclinical dose of lithium carbonate proved helpful in keeping mild cognitive impairment from progressing, during the two year study. If I get to the point of being diagnosed, I'll ask my GP for it based on this.