Bad news for statin takers who want to be physically fit!
... University of Missouri researchers found that simvastatin, a generic type of statin previously sold under the brand name "Zocor," hindered the positive effects of exercise for obese and overweight adults.
"Daily physical activity is needed to maintain or improve fitness, and thus improve health outcomes. However, if patients start exercising and taking statins at the same time, it seems that statins block the ability of exercise to improve their fitness levels."
Statins significantly affected participants' exercise outcomes. Participants in the exercise-only group increased their cardiorespiratory fitness by an average of 10 percent compared to a 1.5 percent increase among participants also prescribed statins. Additionally, skeletal muscle mitochondrial content, the site where muscle cells turn oxygen into energy, decreased by 4.5 percent in the group taking statins while the exercise-only group had a 13 percent increase, a normal response following exercise training. [emphasis mine]
In addition, inhaling vehicle exhaust turns good cholesterol into bad and causes inflammation. So if a statin taker were to jog in urban areas or near heavily traveled roads, health could actually be made worse by that exercise.
Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.
In addition to changing HDL from "good" to "bad," the inhalation of emissions activates other components of oxidation, the early cell and tissue damage that causes inflammation, leading to hardening of the arteries,...
As a diabetic, I was especially alarmed by the damage statins do to mitochondria. I recently was taken off statins, and now I don't regret it. I will also avoid exercising on busy roads, absolutely!