Researchers examined medical records of 6 million Danish adults from 1996 to 2016, comparing health outcomes after taking various NSAIDS.
Diclofenac is sold under various brand names, including Voltaren, Cambia, and Solaraze, both over-the-counter and via prescription.
... people who took diclofenac were 50 percent more likely to have cardiovascular problems in the first 30 days after use than were people who took nothing. They were also about twice as likely to develop problems than people who took other NSAIDs or acetaminophen. The relatively increased risk was seen across the board, including in people who took a lower dose as well as those at low risk of cardiovascular disease. Diclofenac use overall was also associated with a higher risk of gastrointestinal bleeding compared to most other NSAIDs and acetaminophen, but its risk was similar to the NSAID naproxen (commonly sold as Aleve).