Pesticide linked to three generations of disease: Methoxychlor caus...

Methoxychlor , also called Chemform, Methoxo, Metox or Moxie, has been used since 1949. It's epigenetic changes to your parents or grandparents could cause your kidney or ovary disease, or obesity now.

Researchers say ancestral exposures to the pesticide methoxychlor may lead to adult onset kidney disease, ovarian disease and obesity in future generations.

"What your great-grandmother was exposed to during pregnancy, like the pesticide methoxychlor, may promote a dramatic increase in your susceptibility to develop disease, and you will pass this on to your grandchildren in the absence of any continued exposures,"...

Methoxychlor -- also known as Chemform, Methoxo, Metox or Moxie -- was introduced in 1948 and widely used during the 1970s as a safer replacement for DDT. It was used on crops, ornamental plants, livestock and pets. It is still used in many countries around the world.

It was banned in the U.S. in 2003 due to its toxicity and ability to disrupt endocrine systems. Methoxychlor can behave like the hormone estrogen and profoundly affects the reproductive system.

When Skinner and his colleagues exposed gestating rats to methoxychlor at a range typical of high environmental exposures, they saw increases in the incidence of kidney disease, ovary disease and obesity in offspring spanning three generations. The incidence of multiple diseases increased in the third generation or "great-grandchildren."

The researchers say the pesticide may be affecting how genes are turned on and off in the progeny of an exposed animal, even though its DNA and gene sequences remain unchanged.

This is called transgenerational epigenetic inheritance. In recent years, the Skinner lab has documented epigenetic effects from a host of environmental toxicants, including DDT, plastics, pesticides, fungicides, dioxins, hydrocarbons and the plasticizer bisphenol-A or BPA.

He suggests that ancestral exposures to methoxychlor over the past 50 years in North America may play a part in today's increasing rates of obesity and disease. [emphasis mine]

Tags: methoxychlor, obesity, transgenerational epigenetic inheritance

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