Researchers from Case Western Reserve University and Dartmouth have discovered that the shell of a simple plant virus harmlessly and vigorously induces the immune system to fight multiple forms of cancer in mice. Moreover, it prevents the cancer from coming back. Per the article:
The idea is to put something inside a tumor and disrupt the environment that suppresses the immune system, thus allowing the natural defense system to attack the malignancy. That something--the hard coating of cowpea mosaic virus--caused no detectible side effects, which are a common problem with traditional therapies and some immunotherapies. "The cowpea virus-based nanoparticles act like a switch that turns on the immune system to recognize and fight against the tumor -- as well as to remember it," said Nicole Steinmetz, an assistant professor of biomedical engineering at Case Western Reserve, appointed by the Case Western Reserve School of Medicine. "The particles are shockingly potent," said Steven Fiering, professor of microbiology and immunology at Dartmouth's Geisel School of Medicine. "They're easy to make and don't need to carry antigens, drugs or other immunostimmulatory agents on their surface or inside."…. The researchers first switched on the immune system in mice to attack B16F10 lung melanoma or skin melanoma, leaving the mice tumor-free. When the treated mice were later injected with B16F10 skin melanoma (to re-challenge the cured mice), four out of five mice were soon cancer free and one had a slow-growing tumor. The nanoparticles proved effective against ovarian, breast and colon tumor models. Most of the tumors deteriorated from the center and collapsed. The systemic response prevented or attacked metastatic disease, which is the deadliest form of cancer….The team's research is published in the journal Nature Nanotechnology.
John, thank you. Those of us in the Cancer Group would be glad if you would also post these factual cancer articles in our group. Please take a look and join for the greater benefit.
I would like to see it get put on a fast track for human testing. There are a lot of people who would have very little to lose in giving it a try.
This is a massive boost.
One more arrow in the quiver. I suspect the day is not long in coming when cancer will become an endangered species!